Steeds RP et al. |
Altered Coronary Arterial Reactivity Following Pharmacological Perinatal Interventions
Journal of Clinical and Basic Cardiology 2002; 5 (1): 109-114
PDF Summary Figures
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Koronararterie - Prostaglandin
Figure 1: Isolated coronary artery reactivity to prostaglandin F2a effect of increasing concentrations of prostaglandin F2a (PGF2a) on tension in isolated rat coronary arteries mounted on a wire myograph. Results are expressed as mean change in tension (mN/mm) +/- SEM. PNLN: adult male rats exposed to perinatal L-NAME (n = 13 vessels); PNCH: adult male rats exposed to perinatal hypoxia (n=12 vessels); PNC: control adult male rats (n = 15 vessels)
Keywords: Concentration,
Contraction,
coronary artery,
Diagramm,
Kontraktion,
Konzentration,
Koronararterie,
Prostaglandin,
Prostaglandin
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Koronararterie - Kaliumchlorid
Figure 2: Isolated coronary artery reactivity to potassium chloride effect of increasing concentrations of potassium chloride (KCl) on tension in isolated rat coronary arteries mounted on a wire myograph. Results are expressed as mean change in tension (mN/mm) +/- SEM. PNLN: adult male rats exposed to perinatal L-NAME (n = 13 vessels); PNCH: adult male rats exposed to perinatal hypoxia (n = 12 vessels); PNC: control adult male rats (n = 15 vessels)
Keywords: Concentration,
Contraction,
coronary artery,
Diagramm,
Kaliumchlorid,
Kontraktion,
Konzentration,
Koronararterie,
Potassium chloride
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Koronararterie - Acetylcholin
Figure 3: Isolated coronary artery reactivity to acetylcholine effect of increasing concentrations of acetylcholine (ACh) on tension in isolated rat coronary arteries mounted on a wire myograph and pre-constricted with PGF2a. ACh caused a fall in tension (dilatation), which is calculated as a %-fall of the maximum rise in tension with PGF2a. Results are expressed as mean change in tension (mN/mm) +/- SEM. PNLN: adult male rats exposed to perinatal L-NAME (n = 13 vessels); PNCH: adult male rats exposed to perinatal hypoxia (n = 12 vessels); PNC: control adult male rats (n = 15 vessels)
Keywords: Acetylcholin,
acetylcholine,
Concentration,
coronary artery,
Diagramm,
Dilatation,
Dilatation,
Konzentration,
Koronararterie
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Koronararterie - L-NAME
Figure 4A-B: Coronary artery reactivity to L-NAME in (A) isolated coronary arteries, (B) isolated perfused heart preparation. A. Mean +/- SEM rise in tension with 100 mmol/L LNAME in isolated coronary arteries mounted on a wire myograph. PNLN (n = 13 vessels); PNCH (n = 12 vessels); PNC (n = 15 vessels) B. Rise in coronary artery pressure with 10 mmol/L LNAME in isolated blood perfused hearts. PNLN (n = 4 rats); PNCH (n = 4 rats); PNC (n = 6 rats). Results are expressed as mean change in tension (mN/mm)/mmHg +/- SEM
Keywords: coronary artery,
Druck,
heart,
Herz,
Kontraktion,
Koronararterie,
L-NAME,
L-NAME,
Ng-Nitro-L-Arginin-Methylester,
Ng-nitro-L-arginine-methyl-ester,
Perfusion,
Perfusion,
pressure
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Perfundiertes Herz - Druck
Figure 5: Pressure flow lines from isolated perfused heart preparations. The mean pressure-flow relationship in isolated blood perfused hearts. PNLN: adult male rats exposed to perinatal L-NAME (n = 7 rats); PNCH: adult male rats exposed to perinatal hypoxia (n = 5 rats); PNC: control adult male rats (n = 5 rats)
Keywords: Diagramm,
Druck,
heart,
Herz,
hypoxia,
Hypoxie,
L-NAME,
L-NAME,
Perfusion,
Perfusion,
pressure
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