Effects of a Bradycardic Agent (DK-AH 269) on Haemodynamics and Oxygen Consumption of Isolated Blood-Perfused Rabbit Hearts

Granetzny A; Gams E; Schipke JD; Schwanke U

Granetzny A et al.

Effects of a Bradycardic Agent (DK-AH 269) on Haemodynamics and Oxygen Consumption of Isolated Blood-Perfused Rabbit Hearts

Journal of Clinical and Basic Cardiology 2000; 3 (3): 191-196

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Figure

Maximize View	Langendorff-Apparat Figure 2: Modified Langendorff-Apparatus. The coronary perfusion circuit is shown on the left, and the systemic circuit is shown on the right. For details, see text. Keywords: circulation, Langendorff apparatus, Langendorff-Apparat, Schema, Zirkulation


Maximize View	Langendorff-Apparat - Herzfrequenz Figure 3: The heart rate (HR) was significantly reduced with DK. Mean +/- SD during pacing (EP), DK-AH 269 10-6 M (DK+EP) and without pacing (DK-EP), *p = 0.02 Keywords: Diagramm, heart rate, Herzfrequenz, Langendorff apparatus, Langendorff-Apparat


Maximize View	Langendorff-Apparat - linksventrikulärer Druck Figure 4: The peak left ventricular pressure (LVPmax) was reduced with DK (top); dP/dtmax was constant with DK+EP and was diminished without pacing (bottom). Mean +/- SD during pacing (EP), DK-AH 269 10-6 M (DK+EP) and without pacing (DK-EP) Keywords: Diagramm, Langendorff apparatus, Langendorff-Apparat, left ventricular pressure, linksventrikulärer Druck


Maximize View	Langendorff-Apparat - linksventrikulärer Druck Figure 5: The end-diastolic left ventricular pressure (LVP ) was significantly decreased with DK after pacing was terminated. Mean +/- SD during pacing (EP), DK-AH 269 10-6 M (DK+EP) and without pacing (DK-EP), *p = 0.03 Keywords: Diagramm, Langendorff apparatus, Langendorff-Apparat, left ventricular pressure, linksventrikulärer Druck


Maximize View	Langendorff-Apparat - koronarer Blutfluß Figure 6: The global coronary blood flow (CBF) was reduced with DK+EP and remained constant after pacing was terminated (top) while the coronary blood flow per beat (CBF/beat) was increased in the last experimental step (bottom). Mean +/- SD during pacing (EP), DK-AH 269 10-6 M (DK+EP) and without pacing (DK-EP) Keywords: blood flow, Blutfluss, Diagramm, Langendorff apparatus, Langendorff-Apparat


Maximize View	Langendorff-Apparat - myokardialer Sauerstoffverbrauch Figure 7: The myocardial oxygen consumption was decreased with DK+EP and furthermore with DK alone. Mean +/- SD during pacing (EP), DK-AH 269 10-6 M (DK+EP) and without pacing (DK-EP) Keywords: Diagramm, Langendorff apparatus, Langendorff-Apparat, myocardium, Myokard, oxygen consumption, Sauerstoffverbrauch