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Figures and Graphics
Holzmann S et al.  
Dose-response curves of vasorelaxants: computerized calculation of combination effects using the example of nicorandil

Journal of Clinical and Basic Cardiology 1999; 2 (1): 96-98

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Figure
 
Dosiswirkungsbeziehung - Nitroprussid
Figure 1: Cumulative dose-response curves (DRCs) of nitroprusside in the absence (open symbol) and presence of 3-20 micromol/L nicorandil (filled symbols), a) in the absence, b) in the presence of 1 micromol/L glibenclamide. The symbols and bars represent experimental mean values from 12 experiments and 95 % CI. Experimental DRCs are shown by solid lines, theoretical DRCs by dashed lines (dose-additivity) and dotted lines independence). For graphical clarity, the following theoretical curves are shown in a) bands of 95 % CI with upper and lower boundary of dose-additive combinations of nitroprusside in the presence of 3 and 20 micromol/L nicorandil, curve of mean independent effect of nitroprusside in the presence of 20 micromol/L nicorandil, b) means of dose-additive combinations of nitroprusside with 3, 10, and 20 micromol/L nicorandil. The effects of nicorandil alone are shown on the y-axis. Significant deviation from dose-additivity is indicated by asterics.


Keywords: DiagrammGlibenclamidglibenclamideNicorandilNicorandilvasorelaxationvasorelaxation
 
 
Dosiswirkungsbeziehung - Cromakalim
Figure 2: Cumulative dose-response curves (DRCs) of cromakalim in the absence (open symbol) and presence of 10 and 50 micromol/L nicorandil (filled symbols), a) in the absence, b) in the presence of 10 micromol/L methylene blue analogous to Figure 1. The symbols and bars represent experimental mean values from 6-12 experiments and 95 % Cl. The following theoretical curves are shown in a) bands of 95 % CI of dose-additive effects of cromakalim in the presence of 10 micromol/L nicorandil, means of independent effects of cromakalim in the presence of 10 and 50 micromol/L nicorandil, b) 95 % CI bands of dose-additive combinations of cromakalim in the presence of 10 and 50 micromol/L nicorandil.


Keywords: CromakalimCromakalimDiagrammMethylenblaumethylene blueNicorandilNicorandilvasorelaxationvasorelaxation
 
 
 
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