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Figures and Graphics
Auer J et al.  
Homocysteine and Risk of Cardiovascular Disease

Journal of Clinical and Basic Cardiology 2001; 4 (4): 261-264

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Figure
 
Homocystein - Metabolismus
Figure 1: Pathways of homocysteine metabolism (CBS = cystathionine-beta-synthase; Cbl = cobalamin; THF1 = monoglutamated form of tetrahydrofolate; B6 = vitamin B6; CH3 = Methyl). Homocysteine is metabolized either by transsulfuration to cysteine (in a reaction catalyzed by cystathionine-beta-synthase [(CBS] with vitamin B6 as cofactor) or by remethylation to methionine. Remethylation is catalyzed by methionine synthase (and 5,10 methylenetetrahydrofolate reductase). Methionine synthase is dependent upon cobalamin (vitamin B12) as cofactor and folate as cosubstrate. An alternative remethylation pathway (not shown in the figure) uses the cobalamin independent betain-homocysteine methyltransferase.


Keywords: HomocysteinhomocysteinemetabolismMetabolismusSchema
 
 
 
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