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Schlegel U  
Central Nervous System Toxicity of Chemotherapy

European Association of NeuroOncology Magazine 2011; 1 (1): 25-29

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Figure
 
FLAIR
Figure 1: Cerebral MRI (FLAIR) of a 35-year-old male, treated with MTX-based chemotherapy and whole-brain irradiation at the age of 20: ongoing complete response of a high-grade malignant Non-Hodgkin’s B-cell lymphoma. Cognitive dysfunction due to leukoencephalopathy and deep-brain atrophy.


Keywords: FLAIRMRI
 
 
MRI
Figure 2a-b: (a) MRI (T2-weighted) of the cervicothoracic spine showing extensive myelopathy (arrows) after intrathecal MTX 12 mg, Ara-C 30 mg + prednisolone 2.5 mg in a 31-year-old male treated for leukaemia (“triple therapy“): tetraplegia developing over 24 hours shortly after application. (b) Cerebral MRI of the same patient (FLAIR) showing affection of the pons (arrow) and medulla (arrow) resulting in coma and mechanic ventilation. Incomplete recovery with persistent paraparesis and severe bilateral hyakusis.


Keywords: FLAIRMRI
 
 
 
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