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Borchard U Pharmacological properties of beta-adrenoceptor blocking drugs Journal of Clinical and Basic Cardiology 1998; 1 (1): 5-9 PDF Overview
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Figure/Graphic 1: Betablocker - Metabolismus Metabolic pathways of ß-adrenoceptor blocking drugs in the liver. Glu = Glucuronide. The numbers indicate the following metabolic pathways: 1) Glucuronidation of the drug at the OH group of the side chain. 2) Aromatic hydroxylation and subsequent glucuronidation partly combined with the steps described under 3 and 4 (---). 3) Oxidative desamination. 4) Ether cleavage to phenol. 5) N-desalcylation. |
Figure/Graphic 1: Betablocker - Metabolismus
Metabolic pathways of ß-adrenoceptor blocking drugs in the liver. Glu = Glucuronide. The numbers indicate the following metabolic pathways: 1) Glucuronidation of the drug at the OH group of the side chain. 2) Aromatic hydroxylation and subsequent glucuronidation partly combined with the steps described under 3 and 4 (---). 3) Oxidative desamination. 4) Ether cleavage to phenol. 5) N-desalcylation. |