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Erdmann E
Chronic cardiac insufficiency: therapy with beta-adrenergic blockers
Journal of Clinical and Basic Cardiology 1998; 1 (1): 10-14

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This Image - Fig. 3: Herz - Kontraktionskraft Fig. 4A-B: CIBIS II - Überleben Fig. 5: CIBIS-II - Bisoprolol-Titration
Figure/Graphic 3: Herz - Kontraktionskraft
In human myocardium force of contraction increases with the frequency. This is, however, only true for a normal, non-failing myocardium. In heart failure the force of contraction decreases with increasing frequency of contraction. Thus, a high heart rate may lead to deterioration of the patient.
 
Herz - Kontraktionskraft
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Figure/Graphic 3: Herz - Kontraktionskraft
In human myocardium force of contraction increases with the frequency. This is, however, only true for a normal, non-failing myocardium. In heart failure the force of contraction decreases with increasing frequency of contraction. Thus, a high heart rate may lead to deterioration of the patient.
 
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