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Dia-Präsentation von Merck Gesellschaft mbH.
Micardis(R) - Micardis Plus(R) - Pharmakologie (14 Abbildungen)
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Abb. 0: FÜR ÖSTERREICH: Weitere Informationen: Merck Gesellschaft mbH, Zimbagasse 5, 1147 Wien, Tel.: 01/576 00-0 Abb. 1: Pharmakologie Aktuelles Bild - Abb. 2: Angiotensin-II-Antagonisten Abb. 3: Telmisartan - Röntgenstruktur Abb. 4: Angiotensin-I-Rezeptor Abb. 5: Plasma-Halbwertzeit Abb. 6: Angiotensin-I-Rezeptorblocker - Verteilungsvolumina Zum letzten Bild
Abbildung 2: Angiotensin-II-Antagonisten
Telmisartan, a potent and highly selective AT1 receptor antagonist, displays a novel bis-benzimidazole structure. This unique feature of telmisartan accounts for both its high receptor affinity and its excellent pharmacokinetic properties.1 This slide shows the active metabolites of losartan, candesartan and olmesartan. The chemical structures of valsartan, irbesartan and eprosartan are also shown. 1. Ries UJ, et al. 6-Substituted benzimidazoles as new nonpeptide angiotensin II receptor antagonists: synthesis, biological activity, and structure–activity relationships. J Med Chem 1993; 36: 4040–4051.
 
Angiotensin-II-Antagonisten
Vorheriges Bild Nächstes Bild   


Abbildung 2: Angiotensin-II-Antagonisten
Telmisartan, a potent and highly selective AT1 receptor antagonist, displays a novel bis-benzimidazole structure. This unique feature of telmisartan accounts for both its high receptor affinity and its excellent pharmacokinetic properties.1 This slide shows the active metabolites of losartan, candesartan and olmesartan. The chemical structures of valsartan, irbesartan and eprosartan are also shown. 1. Ries UJ, et al. 6-Substituted benzimidazoles as new nonpeptide angiotensin II receptor antagonists: synthesis, biological activity, and structure–activity relationships. J Med Chem 1993; 36: 4040–4051.
 
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