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Fitzgerald JS, Poehlmann TG, Suman P, Gupta SK, Schleussner E, Markert UR Signal Transducer and Activator of Transcription 3 (STAT3) and Trophoblast Invasion Journal für Reproduktionsmedizin und Endokrinologie - Journal of Reproductive Medicine and Endocrinology 2007; 4 (6): 322-330 Volltext (PDF) Summary Übersicht
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Abbildung 2: Jak-STAT signal transducing pathway Jak-STAT signal transducing pathway – 1: cytokine binding to receptor; 2: receptor aggregation; 3: Jaks phosphorylate and activate each other and inner receptor ligand; 4: STATs bind to inner receptor ligand; 5: STATs are activated by Jaks; 6: activated STATs dissociate to form homoand heterodimers; 7: STATs translocate into nucleus; 8: STATs accelerate transcription of target proteins. |
Abbildung 2: Jak-STAT signal transducing pathway
Jak-STAT signal transducing pathway – 1: cytokine binding to receptor; 2: receptor aggregation; 3: Jaks phosphorylate and activate each other and inner receptor ligand; 4: STATs bind to inner receptor ligand; 5: STATs are activated by Jaks; 6: activated STATs dissociate to form homoand heterodimers; 7: STATs translocate into nucleus; 8: STATs accelerate transcription of target proteins. |