Krause und Pachernegg
Verlag für Medizin und Wirtschaft
Artikel   Bilder   Volltext

Mobile Version
A-  |   A  |   A+
Werbung
 
Summary
Goldstein S  
Beta-Blockers in Severe Heart Failure

Journal of Clinical and Basic Cardiology 2002; 5 (2): 155-158

PDF    Summary   




Keywords: BetablockerHerzinsuffizienzbeta-blockerheart failure

Beta-blockers have been demonstrated to have a significant benefit in the treatment of heart failure. Nevertheless there is a reluctance to use these agents because of their potential adverse effects in patients with severe heart failure. Analysis of the Carvedilol Prospective Randomized Cumulative Survival (COPERNICUS) trial, and the sub-group analysis of the Metoprolol CR/XL Randomized Intervention Trial in Chronic Heart Failure (MERIT-HF) in patients with severe heart failure, in NYHA Class III/IV with left ventricular ejection fraction below 25 % showed a significant survival benefit. In addition the frequency of withdrawal for any reason and for increase in heart failure symptoms were less frequent than in the placebo group. These observations indicate that beta-blockers are safe and effective when administered to patients with severe heart failure who are stable on angiotensin converting enzyme inhibitors.
 
copyright © 2003–2017 Krause & Pachernegg GmbH | Sitemap | Impressum
 
Werbung