|Köppel H et al.|
Ischaemic preconditioning: involvement of adenosine, Gi-proteins, protein kinase C and KATP-channels
Journal of Clinical and Basic Cardiology 1999; 2 (1): 19-21
Keywords: Adenosin, Gi-Proteine, Ischämie, KATP-Kanal, Proteinkinase C, Präkonditionierung, adenosine, Gi-proteins, ischaemia, KATP-channel, preconditioning, Proteinkinase C
Ischaemic preconditioning is known as the phenomenon where a brief episode of myocardial ischaemia renders the myocardium resistant to severe injury caused by a subsequent longer period of ischaemia. The protective effect of preconditioning has been shown in various mammalian species. Since the discovery of this phenomenon of ischaemic preconditioning a lot of studies have been performed to identify the underlying mechanisms. It is well established that adenosine A1-receptors and ATP-sensitive potassium channels play an essential role in ischaemic preconditioning. More recent studies prove evidence that apart from A1-receptors, A3-receptors could also be involved, and that the activation of G-proteins, especially the alpha subunit of the pertussis-sensitive inhibitory G-protein (Gi-protein), as well as activation of the protein kinase C might constitute important steps in intracellular signalling. The exact links among these factors, however, remain to be elucidated. J Clin Basic Cardiol 1999; 2: 19-21.