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Summary
Köppel H et al.  
Ischaemic preconditioning: involvement of adenosine, Gi-proteins, protein kinase C and KATP-channels

Journal of Clinical and Basic Cardiology 1999; 2 (1): 19-21

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Keywords: AdenosinGi-ProteineIschämieKATP-KanalProteinkinase CPräkonditionierungadenosineGi-proteinsischaemiaKATP-channelpreconditioningProteinkinase C

Ischaemic preconditioning is known as the phenomenon where a brief episode of myocardial ischaemia renders the myocardium resistant to severe injury caused by a subsequent longer period of ischaemia. The protective effect of preconditioning has been shown in various mammalian species. Since the discovery of this phenomenon of ischaemic preconditioning a lot of studies have been performed to identify the underlying mechanisms. It is well established that adenosine A1-receptors and ATP-sensitive potassium channels play an essential role in ischaemic preconditioning. More recent studies prove evidence that apart from A1-receptors, A3-receptors could also be involved, and that the activation of G-proteins, especially the alpha subunit of the pertussis-sensitive inhibitory G-protein (Gi-protein), as well as activation of the protein kinase C might constitute important steps in intracellular signalling. The exact links among these factors, however, remain to be elucidated. J Clin Basic Cardiol 1999; 2: 19-21.
 
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