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Brunelli C et al.  
Improvement of ischaemic left ventricular dysfunction in a clinical setting

Journal of Clinical and Basic Cardiology 1999; 2 (1): 61-63

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Keywords: HerzhibernationIschämieNisoldipinhearthibernationischaemianisoldipine

Aim of this study was to investigate the effects of nisoldipine on regional myocardial bloodflow (MBF) in dyssynergic but viable myocardium after myocardial infarction (MI). 15 patients with isolated left anterior descending coronary (LAD) stenosis were studied 1 month after first MI. Patients underwent F18-deoxyglucose imaging, while MBF was measured using positron emission tomography and 13N-ammonia, at baseline and following dobutamine infusion (10 mcg/Kg/min over 5 min, DOB). MBF measurements were repeated 24 hours later after nisoldipine (10 mg bid). Among a total of 132 LAD related regions, 30 showed normal wall motion at 2D-echo and normal metabolic activity, 68 showed wall motion abnormality and preserved deoxyglucose uptake, while 32 dyssynergic regions were necrotic. Reduced baseline MBF values were found in necrotic and dyssynergic viable regions but only viable regions maintained residual perfusion reserve. After nisoldipine treatment a significant improvement in baseline MBF occurred only in viable segments. Thus, in dyssynergic viable myocardium, nisoldipine selectively improved basal perfusion. J Clin Basic Cardiol 1999; 2: 61-3.
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