Renal function and haemodynamics in obese hypertensive patients

Journal of Clinical and Basic Cardiology 1999; 2 (1): 73-74

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Keywords: Adipositas,  Hypertonie,  insuline,  Niere,  regionaler Blutfluss,  hypertension,  insuline,  kidney,  obesity,  regional blood flow

Abdominal obesity and hypertension being linked via insulin resistance lead to kidney impairment. It is of practical interest to estimate the contribution of each factor in the renal circulation and function lesions. The impact of obesity on renal haemodynamic and glomerular filtration of hypertensive subjects was investigated. 17 lean and 30 stout patients with mild to moderate hypertension and normal oral glucose tolerance (OGTT) test were investigated. 19 subjects of the obese group have central fat distribution. The plasma levels of insulin (fasting and during OGTT) and cortisol were assessed by means of radioimmuno assay. The effective renal blood and plasma flow (RBF and RPF) and glomerular filtration rate (GFR) were determined by radionucleide method. RPF and GFR expressed as absolute values and related to the height (but not to the body surface area of 1.73 m2) were higher in hypertensive subjects with abdominal obesity (RPF 492.1 ± 28.3 vs. 418.6 ± 22.3 ml/min, p = 0.02 in lean hypertensives and RPF/height 2.85 ± 0.16 vs. 2.42 ± 0.13 ml/min per cm, p = 0.016, GFR 132.3 ± 9.6 vs. 96.8 ± 12.3 ml/min in lean subjects, p = 0.01 and GFR/height 0.77 ± 0.05 vs. 0.54 ± 0.07 ml/min per cm, p = 0.01, resp.) Abdominal obesity in hypertensive patients is associated with renal vasodilatation and glomerular hyperfiltration which are not caused by direct influence of hyperinsulinemia. J Clin Basic Cardiol 1999; 2: 73-4.