BMIPP imaging for assessing myocardial viability in acute and chronic left ventricular dysfunction

Journal of Clinical and Basic Cardiology 1999; 2 (2): 209-212

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Keywords: Fettsäure,  myokardiale Lebensfähigkeit,  SPECT,  fatty acids,  myocardial viability,  single photon emission computerized tomography

The use of iodine-123-labeled fatty acids is witnessing a resurgence of interest, primarily because of data from recent clinical protocols comparing regional myocardial uptake of 15-(p-iodophenyl)-3-(R,S)-methylpentadecanoic acid (BMIPP) with flow tracers (either thallium or sestamibi). Mismatches in BMIPP and flow tracer distribution (BMIPP < flow tracer) reflect the metabolic shift from fatty acid to glucose utilization in ischaemic myocardium. In this sense, the combined imaging of BMIPP and a flow tracer with single photon emission computerized tomography (SPECT) may provide similar and equally important information as fluor-18 deoxyglucose and positron emission tomography regarding the assessment of myocardial viability. The purpose of this article is to review the clinical impact of BMIPP in patients with acute and chronic left ventricular dysfunction for the identification of jeopardized but viable myocardium and for the prediction of functional outcome. J Clin Bas Cardiol 1999; 2: 209-12.