Beta-blockers and non-cardiac surgery
Journal of Clinical and Basic Cardiology 2001; 4 (1): 21-23
Keywords: Betablocker, Chirurgie, Mortalitšt, beta-blocker, mortality, surgery
Morbidity and mortality resulting from cardiac ischaemia are a major cause of severe complications in patients undergoing non-cardiac surgery. Peri- and postoperative ischaemia are most likely caused by an increase in myocardial oxygen demand in patients with coronary heart disease and those in whom coronary plaque ruptures may be triggered. Increased catecholamine levels and prothrombotic tendencies play an important role in these events. The perioperative risk is highest among patients with coronary heart disease, prior myocardial infarction, congestive heart failure, arterial hypertension and diabetes mellitus. Since beta-blockers directly inhibit the effects of catecholamines they should be given to patients undergoing non-cardiac surgery that have one of these risk factors but no major contraindications. Even if the drugs cause complications they usually can be tolerated during the perioperative period. J Clin Basic Cardiol 2001; 4: 21-23.