|Köppel H et al.|
Correlation between activated protein C-resistance and factor V Leiden mutation
Journal of Clinical and Basic Cardiology 2001; 4 (1): 73-74
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Keywords: aktivierte Protein C-Resistenz, COATEST, Faktor-V-Leiden, Venenthrombose, APC-resistance, COATEST, Faktor-V-Leiden, venous thrombosis
Factor V Leiden has been shown to be one important genetic risk factor for venous thrombosis due to poor response to activated protein C. However, several publications suggest that genetic mutation might constitute only one factor causing resistance towards activated protein C (APC-R) and that other risk factors, such as alcohol consumption, cholesterol levels or acute phase reactants could lead to APC-R, too. This, in turn, would mean that existence of factor V Leiden mutation could only be detected witha a genetic test, while resistance towards APC can be found with a biochemical test, the so-called "COATEST". In our paper we demonstrate the correlation of APC-R and existence of factor V Leiden mutation in all investigated individuals. Our results clearly point out the crucial role of factor V Leiden mutation in the development of APC-R. The performance of both the genetic and the biochemical test may thus be redundant. J Clin Basic Cardiol 2001; 4: 73-74.