|Seeger H, Mueck AO|
Estradiol Metabolites and their Possible Role in Gynaecological Cancer
Journal für Reproduktionsmedizin und Endokrinologie - Journal of Reproductive Medicine and Endocrinology 2010; 7 (Sonderheft 1): 62-66
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Keywords: estradiol, Gynäkologie, Metabolit, estradiol metabolites, gynaecological malignancies
Evidence is growing that certain estradiol metabolites are biologically active, especially in the field of cancer. Currently research focuses on the anticancerogenic effects of 2-hydroxyestrone and particularly 2-methoxyestradiol, as well as the possible carcinogenic properties of 4-hydroxyestrogens and 16α-hydroxyestrone. The clinical relevance of these activities, demonstrated in in vitro and animal experiments, remains unclear – it is proven, however, that the metabolite production can be altered in certain malignancies such as endometrial-, breast- and cervical carcinoma. Clinical studies, including own investigations, demonstrated a negative correlation between the ratio of 2-hydroxyestrone to 16α-hydroxyestrone and breast cancer risk. However, the design and interpretation of such studies should consider factors influencing metabolic pattern such as diet, physical activity, smoking as well as internal diseases and certain drugs.