Oxidized low-density lipoproteins and atherosclerosis

Journal of Clinical and Basic Cardiology 2000; 3 (2): 87-88

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Keywords: antioxidative Mechanismen,  Atherogenese,  Freie Radikale,  oxidative Mechanismen,  antioxidative mechanisms,  atherogenesis,  free radicals,  oxidative mechanisms

Basic research has provided strong evidence that LDL oxidation plays an important role in atherogenesis. Several mechanisms have been identified which can lead to LDL oxidation in vivo. Clinical and epidemiological studies have provided circumstancial evidence that oxidized LDL may be involved in the progression of atherosclerotic vascular disease. Better understanding of mechanisms that lead to LDL oxidation or protect LDL against oxidative damages should help the development of new strategies for the prevention of cardiovascular diseases. J Clin Basic Cardiol 2000; 3: 87?8.