Abbildung 5: Telmisartan - Renoprotektiver Effekt
Redón et al. conducted a 12-month study to assess the interactions between RAAS gene polymorphisms and telmisartan therapy in patients with mild-to-moderate hypertension.1 There was no correlation between RAAS gene polymorphisms and the response to telmisartan. Of the 206 patients, 28% had microalbuminuria (urinary albumin excretion [UAE] >30 mg/day), and mean UAE was 32.7 mg/day. After 3 months, telmisartan significantly reduced albuminuria by 52%, and this was reduced further to a 69% reduction by the end of the study. 1. Redón J, et al. Renin-angiotensin system gene polymorphisms: relationship with blood pressure and microalbuminuria in telmisartan-treated hypertensive patients. Pharmacogenomics J 2005; 5: 14–20.