Abbildung 8: Telmisartan - Renoprotektiver Effekt
In DETAIL, the steepest decline in GFR was seen in the first year.1 This was probably a haemodynamic effect, associated with the lowering of systemic blood pressure that results in reduced intraglomerular pressure.2 Thereafter, the rate of decline was markedly reduced with a consistent, year-on-year effect. The mean decline in GFR of patients in the telmisartan group was 3.7 ml/min/1.73 m2/year in those who completed the study, and 3.6 ml/min/1.73 m2/year in the LOCF dataset. In the enalapril group, the mean rate of GFR decline was 3.3 ml/min/1.73 m2/year in those who completed the study, and 3.1 ml/min/1.73 m2/year in the last observation carried forward dataset. 1. Barnett A, et al. Angiotensin-receptor blockade versus converting-enzyme inhibition in type 2 diabetes and nephropathy. N Engl J Med 2004; 351: 1952–1961. 2. Levey AS, et al. Short-term effects of protein intake, blood pressure, and antihypertensive therapy on glomerular filtration rate in the Modification of Diet in Renal Disease Study. J Am Soc Nephrol 1996; 7: 2097–2109.