Abbildung 14: Telmisartan - Arterienelastizität
Arterial stiffness is an independent risk factor for cardiovascular mortality.1 Pulse wave velocity increases as vascular stiffness increases, and can cause increased SBP. In this study, 28 patients with type 2 diabetes and mild-to-moderate hypertension were given placebo or telmisartan 40 mg for 3 weeks in a cross-over design with 2-week placebo wash-out.2 Telmisartan significantly reduced pulse wave velocity along the carotid-femoral route, with improvements along the carotid-radial route approaching significance. 1. Laurent S, et al. Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients. Hypertension 2001; 37: 1236–1241. 2. Asmar R, et al. Effects of telmisartan on arterial stiffness in Type 2 diabetes patients with essential hypertension. J Renin Angiotensin Aldosterone Syst 2002; 3: 176–180.