Reoperation for Recurrent Glioblastoma: Outcome Analysis and Correlation with MGMT Status
European Association of NeuroOncology Magazine 2014; 4 (1): 16-19
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Keywords: glioblastoma, MGMT methylation, prognostic factor, recurrence, second surgery
The treatment of recurrent glioblastoma remains a challenge. Although second surgery may provide effective palliation, it has yet to be established whether it has a role at all. The few studies investigating this issue are small, retrospective, and characterized by inhomogeneous datasets. Moreover, the role of MGMT at the time of relapse remains controversial, since MGMT status may vary across the disease’s natural history and its impact on post-progression survival is unclear. The aim of this study was therefore to analyze predictors of outcome in patients with recurrent glioblastoma and to compile a review of data in the literature with a view to comparing the effect on outcome of second surgery against wellknown prognostic determinants.
European Association of NeuroOncology Magazine 2014; 4 (1): 16-19
PDF Summary
Keywords: glioblastoma, MGMT methylation, prognostic factor, recurrence, second surgery
The treatment of recurrent glioblastoma remains a challenge. Although second surgery may provide effective palliation, it has yet to be established whether it has a role at all. The few studies investigating this issue are small, retrospective, and characterized by inhomogeneous datasets. Moreover, the role of MGMT at the time of relapse remains controversial, since MGMT status may vary across the disease’s natural history and its impact on post-progression survival is unclear. The aim of this study was therefore to analyze predictors of outcome in patients with recurrent glioblastoma and to compile a review of data in the literature with a view to comparing the effect on outcome of second surgery against wellknown prognostic determinants.