Genetic Aspects of Premature Ovarian Failure
Journal für Reproduktionsmedizin und Endokrinologie - Journal of Reproductive Medicine and Endocrinology 2009; 6 (1): 17-18
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Keywords: Chromosomenaberration, Genmutation, Humangenetik, POF, chromosome aberration, gene mutation, premature ovarian failure
Premature ovarian failure (POF) is characterized by the combination of amenorrhea before age 40 years and hypergonadotropic hypogonadism. The prevalence is approximately 1 %. Genetic causes of POF include chromosome aberrations and monogenic defects. Furthermore, polygenic-multifactorial inheritance can be assumed in a subset of cases.
Journal für Reproduktionsmedizin und Endokrinologie - Journal of Reproductive Medicine and Endocrinology 2009; 6 (1): 17-18
Volltext (PDF) Summary Praxisrelevanz Abbildungen
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Keywords: Chromosomenaberration, Genmutation, Humangenetik, POF, chromosome aberration, gene mutation, premature ovarian failure
Premature ovarian failure (POF) is characterized by the combination of amenorrhea before age 40 years and hypergonadotropic hypogonadism. The prevalence is approximately 1 %. Genetic causes of POF include chromosome aberrations and monogenic defects. Furthermore, polygenic-multifactorial inheritance can be assumed in a subset of cases.