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1. Cazorla A;
Fohlen M;
Ferrand-Sorbets S;
Polivka M
Case Report
Tumoral proliferation
European Association of NeuroOncology Magazine 2014; 4 (3): 124-126
Histopathological and immunohistochemical findings (A: HES *50, B: HES *200, C: HES *400 and D: GFAP *400) Keywords: histopathological finding,
tumour
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2. Nakai K;
Yamamoto T;
Kumada H;
Matsumura A
Boron Neutron Capture Therapy for Glioblastoma: A Phase-I/II Clinical Trial at JRR-4
GBM patient
European Association of NeuroOncology Magazine 2014; 4 (3): 116-123
(a) Serial MRI image of the GBM patient treated with protocol IV. The scalp
was unremarkable. Hair loss continued for more than 1 year. (b) Recurrent GBM patient
who underwent BNCT after 60-Gy irradiation. The tumour was stable for more
than 3 years. Keywords: GBM,
glioblastoma,
MRI,
tumour
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3. Götz I;
Grosu AL;
Spehl TS
Role of PET Imaging in Patients with High-Grade Gliomas undergoing anti-angiogenic Therapy with Bevacizumab – Review of the Literature and Case Report
Distant Tumour
European Association of NeuroOncology Magazine 2014; 4 (3): 102-108
(A) T1-weighted MRI, (B) parametric 18F-FET-PET, and (C) fused images of a
distant tumour manifestation in the mesencephalon. Note that the Gd-enhancing lesion
on the T1-weighted MRI is rather small and only visible on the left side, whereas
the extent of 18F-FET uptake is much larger and extends to the right side. Keywords: MRI,
tumour
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4. Mitsuya K;
Nakasu Y
Metastatic Skull Tumours: Diagnosis and Management
Calvarial metastasis
European Association of NeuroOncology Magazine 2014; 4 (2): 71-74
A 70-year-old woman with calvarial metastasis from lung cancer presenting with cosmetic problem in the forehead. (a) Pre-enhanced axial and (b) post-enhanced sagittal MR images demonstrating a mass lesion with focal invasion into the skin and dura mater. (c) Skull X-rays showing an osteolytic lesion (white arrow), and (d) surgical results of resection with a wide margin and reconstruction in the frontal bone (arrow heads). Keywords: calvarial metastasis,
MRI,
x-ray
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5. Mitsuya K;
Nakasu Y
Metastatic Skull Tumours: Diagnosis and Management
Calvarial metastasis
European Association of NeuroOncology Magazine 2014; 4 (2): 71-74
(a) T1-weighted, gadolinium-enhanced MR axial images of a 58-year-old woman with calvarial metastasis from breast cancer presenting with headache. (b) The tumour became less enhanced 3 years after 40 Gy per 20 fractions radiation therapy. Keywords: calvarial metastasis,
MRI
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6. Mitsuya K;
Nakasu Y
Metastatic Skull Tumours: Diagnosis and Management
Calvarial metastasis
European Association of NeuroOncology Magazine 2014; 4 (2): 71-74
MR images of a 72-year-old man with calvarial metastasis from cholangiocarcinoma presenting with hemiparesis and partial seizures. (a) Coronal, T1-weighted, gadolinium-enhanced MR image demonstrating dural invasion and occlusion of the superior sagittal sinus (white arrow). (b) Axial FLAIR image demonstrating diffuse brain oedema in the left hemisphere. Keywords: axial FLAIR image,
calvarial metastasis,
MRI
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7. Mitsuya K;
Nakasu Y
Metastatic Skull Tumours: Diagnosis and Management
Calvarial metastasis
European Association of NeuroOncology Magazine 2014; 4 (2): 71-74
T1-weighted, gadolinium-enhanced sagittal MR images of a 57-year-old woman with calvarial metastasis from thyroid cancer. (a) Pre- and (b) 3 months postirradiation 40 Gy per 20 fractions. Keywords: calvarial metastasis,
MRI
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8. Mitsuya K;
Nakasu Y
Metastatic Skull Tumours: Diagnosis and Management
Skull-base metastases
European Association of NeuroOncology Magazine 2014; 4 (2): 71-74
Magnetic resonance images of patients with skull-base metastases causing Greenberg’s 5 syndromes. (a) T1-weighted, gadolinium-enhanced MR axial image in a 60-year-old woman with skull-base metastasis from colon cancer presenting with
visual disturbance and double vision (orbital syndrome). (b) T1-weighted, gadoliniumenhanced
MR axial image in a 41-year-old man with skull-base metastasis from lung cancer presenting with diplopia (parasellar syndrome). (c) T1-weighted, gadoliniumenhanced MR axial image in a 72-year-old woman with skull-base metastasis from breast cancer presenting with trigeminal neuralgia (middle-fossa syndrome). (d) T1-weighted, gadolinium-enhanced MR axial image in a 49-year-old woman with skullbase metastasis from melanoma presenting with dysphagia (jugular foramen syndrome).
(e, f) Pre- and post-contrast-enhanced axial MR images in a 70-year-old man
with skull base metastasis from prostate cancer presenting with severe occipitalgia
and dysarthria (occipital condyle syndrome). Keywords: jugular foramen syndrome,
middle-fossa syndrome,
MRI,
occipital condyle syndrome,
orbital syndrome,
parasellar syndrome,
skull-base metastases
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9. Baehring JM
Lymphoma Nerve Infiltration
Mantle cell lymphoma
European Association of NeuroOncology Magazine 2014; 4 (2): 61-64
A 54-year-old man with a history of mantle cell lymphoma presented with tingling along the palmar surface of his left thumb. Then the left thumb, first and second digit started feeling “inflamed, swollen, about to explodeâ€. The pain awakened him at night. At the same time, he felt a burning pain along the heel, lateral and anterior plantar surface of the right foot. Work-up revealed neurolymphomatosis. Multiple mass lesions were identified within the
peripheral nervous system including the left sciatic nerve ([a, b] 18-FDG-PET), the left median nerve (arrow head in [c]; axial T1-weighted MRI of the left forearm; note infiltration of the flexor musculature by tumour), right brachial plexus, right sciatic nerve, and left tibial nerve (not shown). Biopsy of the soft tissue mass in the right forearm
revealed a mantle cell lymphoma.
R: radius; U: ulna Keywords: mantle cell lymphoma,
MRI,
peripheral nervous system,
PET
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10. Grisold W;
Grisold A
Nerve Infiltration: Where, When, and How? An Introduction
Nerve infiltration
European Association of NeuroOncology Magazine 2014; 4 (2): 58-60
(a) Nerve infiltration. A. Nerve compression and invasion. B. Intranerval metastasis. C. Tumour spread within the nerve. D. Intravascular lymphoma. EpineurialV: epineurial vessel; EndoV: endoneurial vessel. (b) Spread of tumours along nerves. R & A: Retrograde and anterograde spread (red arrows). Spread via anastomosis a between different nerve territories Keywords: intranerval metastasis,
intravascular lymphoma,
Invasion,
nerve compression,
nerve infiltration,
scheme,
tumour,
tumour spread
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11. Grisold W;
Grisold A
Nerve Infiltration: Where, When, and How? An Introduction
Meningeal infiltration
European Association of NeuroOncology Magazine 2014; 4 (2): 58-60
Meningeal infiltration. The dura mater continues as the perineurium. In general the tumor cells do not spread beyond this boundary centrifugally. (A) tumour spread in the subarachnoid space. (B) Lumps and nodules consist of tumour cells and have their own vascularisation. RM: spinal cord; DRG: dorsal root ganglion Keywords: dorsal root ganglion,
dura mater,
meningeal infiltration,
perineurium,
scheme,
spinal cord,
subarachnoid space
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12. Moser W;
Marhold F;
Ungersböck K;
Oberndorfer S
Subacute Spinal Cord Cempression Due to an Intramedullar Spinal Teratoma in a 53-Year-Old Female Patient: A Case Report
Spinal Teratoma
European Association of NeuroOncology Magazine 2014; 4 (1): 34-36
Intraoperative pictures: (a) after opening of the dura mater; (b) pus-like liquid appearing during
resection of the tumour; (c) collapse of the myelon
after resection. Keywords: intraoperative picture,
photograph,
spinal teratoma
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13. Grossman R;
Ram Z
Awake Craniotomy in Glioma Surgery
Awake Craniotomy
European Association of NeuroOncology Magazine 2014; 4 (1): 27-33
Kaplan-Meier curve of survival for elderly patients (65 years) with highgrade gliomas (HGG) who underwent awake-craniotomy gross tumour resection (GTR) compared to subtotal resection (STR) or biopsy. Median survival was significantly longer for patients with HGG who underwent GTR compared to those who underwent STR or biopsy (10.8 vs 7.8 months, respectively; p = 0.039) [39]. Keywords: awake craniotomy,
diagram,
glioma surgery,
Kaplan-Meier,
survival distribution
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14. Uckermann O;
Galli R;
Mackenroth L;
Geiger K;
Steiner G;
Koch E;
Schackert G;
Kirsch M
Optical Biochemical Imaging: Potential New Applications in Neuro-Oncology
NLO imaging
European Association of NeuroOncology Magazine 2014; 4 (1): 20-26
Multimodal NLO imaging of human tumours (red: CARS, green: TPEF, blue: SHG), overlaid with the bright field images of the unstained sample. The technique allows to retrieve detailed morphochemical information about tissue structure and properties on unstained samples. (a) Cryosection of human glioblastoma (scale bar: 200 μm). (b) High magnification of the border between tumour and normal tissue as indicated in (a). (c) Cryosection of human neuroma (scale bar: 0.5 mm). Keywords: NLO imaging,
nonlinear optical microscopy
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15. Uckermann O;
Galli R;
Mackenroth L;
Geiger K;
Steiner G;
Koch E;
Schackert G;
Kirsch M
Optical Biochemical Imaging: Potential New Applications in Neuro-Oncology
CARS image
European Association of NeuroOncology Magazine 2014; 4 (1): 20-26
CARS microscopy of infiltrative experimental
glioblastoma in a mouse model: The intensity of the CARS image and the morphological details permit to distinguish between the tumour mass, the infiltrative area, and the normal brain grey and white matters. H&E staining (top) CARS image (centre). The intensity of the CARS signal along the blue line is plotted in the graph (bottom). Mean intensity values for the different types of tissue are also reported. Mean intensity that characterizes the normal grey tissue is reduced to approximately 50 % in the infiltrative area and to approximately 30 % in the tumour. Lipid rich white matter is characterized by high CARS signal intensity (228, saturation in some areas). Keywords: CARS image,
scheme
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16. Jahrestagung der Österreichischen Gesellschaft für Rheumatologie & Rehabilitation
28. - 30. November 2013
Abstracts der Posterpräsentationen
ÖGR-Jahrestagung 2013
Journal für Mineralstoffwechsel & Muskuloskelettale Erkrankungen 2013; 20 (4): 141-165
Studenic P, et al. Proportion of patients treated with conventional synthetic (cs) DMARDSs, combination treatment of csDMARDs with either tumour-necrosis factor inhibitors (TNFi) or non-TNFi-biological originator (bo) DMARDS, and monotherapy with boDMARDs, for each sequential treatment course in percent. Keywords: Diagramm,
Mineralstoffwechsel,
Rheumatoide Arthritis
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17. Zijdewind J;
Wesseling P;
de Witt Hamer PC;
Reijneveld J
Case Report: Primary Leptomeningeal Melanoma in a Patient with Neurocutaneous Melanosis
Leptomeningeal Tumour
European Association of NeuroOncology Magazine 2013; 3 (3): 141-142
Transversal section of contrast-enhanced T1 MRI demonstrating a left frontal, inhomogeneously contrast-enhancing, and space-occupying lesion with oedema in the surrounding brain tissue. Keywords: leptomeningeal tumour,
MRI
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18. Zijdewind J;
Wesseling P;
de Witt Hamer PC;
Reijneveld J
Case Report: Primary Leptomeningeal Melanoma in a Patient with Neurocutaneous Melanosis
Leptomeningeal Tumour
European Association of NeuroOncology Magazine 2013; 3 (3): 141-142
Intraoperative photograph after opening of the dura, showing a black leptomeningeal tumour in the left frontal region. Of note is the spotty black
appearance of the arachnoid, which is not continuous with the tumour, consistent with neurocutaneous melanosis. Keywords: leptomeningeal tumour,
photo
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19. Rössler K;
Coras R;
Blümcke I
Case Report:Long-Term Epilepsy-Associated Giant Lobar Collision Tumour
Brain-Collision-Tumour
European Association of NeuroOncology Magazine 2013; 3 (3): 139-140
Ependymoma component (H & E staining). Keywords: ependymoma,
histology
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20. Rössler K;
Coras R;
Blümcke I
Case Report:Long-Term Epilepsy-Associated Giant Lobar Collision Tumour
Brain-Collision-Tumour
European Association of NeuroOncology Magazine 2013; 3 (3): 139-140
Higher magnification of ganglioglioma component with dysplastic neurons (H & E staining). Keywords: ganglioglioma,
histology
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21. Rössler K;
Coras R;
Blümcke I
Case Report:Long-Term Epilepsy-Associated Giant Lobar Collision Tumour
Brain-Collision-Tumour
European Association of NeuroOncology Magazine 2013; 3 (3): 139-140
Ganglioma component (H & E staining). Keywords: ganglioglioma,
histology
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22. Rössler K;
Coras R;
Blümcke I
Case Report:Long-Term Epilepsy-Associated Giant Lobar Collision Tumour
Brain-Collision-Tumour
European Association of NeuroOncology Magazine 2013; 3 (3): 139-140
Increased proliferation activity as indexed by MIB1 labelling. Keywords: histology,
neuroepithelial tumour
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23. Rössler K;
Coras R;
Blümcke I
Case Report:Long-Term Epilepsy-Associated Giant Lobar Collision Tumour
Brain-Collision-Tumour
European Association of NeuroOncology Magazine 2013; 3 (3): 139-140
Macroscopic appearance of the tumour. Keywords: photo,
tumour
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24. Grisold W;
Soffietti R
Editorial to Special Issue
Nerve-Infiltration
European Association of NeuroOncology Magazine 2013; 3 (3): 94
Spinal nerve root in a patient with lung cancer. Tumour tissue within the nerve root (arrow). Keywords: malignant tumour,
nerve infiltration
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25. Grisold W;
Soffietti R
Editorial to Special Issue
Nerve-Infiltration
European Association of NeuroOncology Magazine 2013; 3 (3): 94
Infiltration of a trigeminal branch in the cavernous sinus by a gliosarcoma (arrow). Keywords: malignant tumour,
nerve infiltration
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27. Rössler K;
Coras R;
Blümcke I
Case Report:Long-Term Epilepsy-Associated Giant Lobar Collision Tumour
Brain-Collision-Tumour
European Association of NeuroOncology Magazine 2013; 3 (3): 139-140
T2 axial MRI, calcification in black. Keywords: intrinsic tumour,
left frontal lobe,
MRI
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28. Rössler K;
Coras R;
Blümcke I
Case Report:Long-Term Epilepsy-Associated Giant Lobar Collision Tumour
Brain-Collision-Tumour
European Association of NeuroOncology Magazine 2013; 3 (3): 139-140
T1 gadolinium-enhanced axial MRI. Keywords: intrinsic tumour,
left frontal lobe,
MRI
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29. Rössler K;
Coras R;
Blümcke I
Case Report:Long-Term Epilepsy-Associated Giant Lobar Collision Tumour
Brain-Collision-Tumour
European Association of NeuroOncology Magazine 2013; 3 (3): 139-140
Cranial CT scan at the age of 14 months. Keywords: CT,
porencephalic cyst
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30. Perneczky G;
Loyoddin M;
Schappelwein H;
Sherif C
Spinal Meningiomas: A Comprehensive Overview and Own Experience
Spinal Menigioma
European Association of NeuroOncology Magazine 2013; 3 (3): 118-121
Postoperative MR scans: (a) T1-weighted contrast-enhanced MR images: the spinal cord (red arrow) is in normal location. No tumour remnants are visible. (b) T2-weighted native MR scan: the surgical dorsal approach and complete tumour
removal are documented. Keywords: MRI,
spinal meningioma
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31. Perneczky G;
Loyoddin M;
Schappelwein H;
Sherif C
Spinal Meningiomas: A Comprehensive Overview and Own Experience
Spinal Meningioma
European Association of NeuroOncology Magazine 2013; 3 (3): 118-121
Pre- and intraoperative findings: (a) T2-weighted native sagittal MR image: the tumour can be nicely delineated (red arrow). (b, c) Axial T1-weighted contrastenhanced sequence: inhomogeneous contrast enhancement is due to intratumoural calcifications (red arrow). (d) Sagittal contrast-enhanced T1-weighted image: again, the calcifications can be seen as contrast agent-free areas within the tumour (red arrow). (e) Intraoperative findings: the spinal cord is carefully mobilized under IOM. The tumour (blue arrow) can be seen at the left ventral dura. Keywords: MRI,
spinal meningioma
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32. Scherer M;
Jungk C;
Unterberg AW
Journey of Intraoperative Magnetic Resonance Imaging into Daily Use: A Review
Seizures
European Association of NeuroOncology Magazine 2013; 3 (2): 61-67
33-year-old male with seizures diagnosed with a WHO °II astrocytoma by stereotactic biopsy. Complete
tumour resection was scheduled. (A) Preoperative definition of target tumour volume of 31.72 cm3 on T2 FLAIR
images. (B) On the first iMRI, a 1.92-cm3 residual tumour is detected at the ventral aspect of the resection cavity
on sharp FLAIR images. (C) Postoperative MRI shows no signs of tumour remnants. iMRI guidance led to a fully
successful procedure with no added neurologic morbidity. Keywords: iMRI,
tumour
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33. Hamerlik P;
Rich JN;
Lathia JD
News and Views Basic Science: Glioblastoma Stem Cells
GSC
European Association of NeuroOncology Magazine 2013; 3 (2): 49-55
Glioblastoma stem cells (GSC) reside in vascular and hypoxic niches. Schematic
representation of GSC residing in a vascular niche supported by blood vessels
and hypoxic niche adjacent to necrotic regions. Each niche promotes the maintenance
of the GSC population and supports the expansion of the tumour mass. Keywords: glioblastoma stem cells,
scheme
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34. Schweppe KW;
Rabe T;
Langhardt M;
Woziwodzki J;
Petraglia F;
Kiesel L
Endometriosis – Pathogenesis, Diagnosis, and Therapeutic Options for Clinical and Ambulatory Care
Deeply infiltrating endometriosis
Journal für Reproduktionsmedizin und Endokrinologie - Journal of Reproductive Medicine and Endocrinology 2013; 10 (Sonderheft 1): 102-119
Deeply infiltrating endometriosis: surgical site. (a): Fibrotic tumour infiltrating the rectum; (b): Resection with good safety margin, saving the posterior wall of the rectum and the mesorectum. Keywords: fibrotic tumour,
infiltrating endometriosis
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35. Pichler J;
Schwarz G
Case Report: Low-Grade Glioma, Refractory Epilepsy, VPA Encephalopathy, and Chemotherapy Supporting Seizure Control: A Complex Case
Tumour
European Association of NeuroOncology Magazine 2013; 3 (1): 25-26
(a, b) MRI: FLAIR; (c) T1 with contrast media showing hyperintense
cortical and subcortical signals with contrast enhancement at the left central
region. (d) FET-PET increased FET metabolism in the left central region. Keywords: FET-PET,
MRI,
Tumor
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36. Proescholdt M;
Doenitz C;
Brawanski A
Surgery of Malignant Gliomas Using Modern Technology
Glioma - Surgery
European Association of NeuroOncology Magazine 2013; 3 (1): 11-14
Quantification of the preoperative tumour volume in malignant gliomas. (A) Axial T1-weighted MRI scan of a patient with a left frontal glioblastoma. (B) The
contrast-enhancing part of each section is outlined and subsequently fused to generate (C) a 3-dimensional segment which can be quantified volumetrically. Keywords: glioma,
MRI,
Tumor
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37. Proescholdt M;
Doenitz C;
Brawanski A
Surgery of Malignant Gliomas Using Modern Technology
Glioma - Surgery
European Association of NeuroOncology Magazine 2013; 3 (1): 11-14
Fusion of [F-18]fluoroethyltyrosine: PET (red), functional MRI (green), and
DTI tractography (yellow) in a patient with a left frontal anaplastic astrocytoma.
Note the close vicinity of eloquent cortical and subcortical structures to the tumour
borders. Keywords: glioma,
MRI,
PET
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38. Reyes-Botero G;
Laigle-Donadey F;
Cornu P;
Mokhtari K
An Exophytic Brainstem Lesion
Brain tumour
European Association of NeuroOncology Magazine 2012; 2 (3): 136
Brain MRI (T1-weighted/gadolinium) showing a contrast-enhanced lesion in the medulla oblongata. The tumour has dorsal exophytic and cystic components. Keywords: brain,
MRI,
Tumor
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39. Wohlgenannt V;
Oberndorfer S;
Grisold W
Intractable Headache in a Glioblastoma Patient
Glioblastoma
European Association of NeuroOncology Magazine 2012; 2 (3): 134-135
T1-weighted MRI (axial) with contrast media, showing enhancement of
the meninges (arrows), and only little enhancement at the primary tumour location
at the left temporobasal area (asterisk). Keywords: glioblastoma,
MRI
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40. Smits M
Functional Magnetic Resonance Imaging (fMRI) in Brain Tumour Patients
Brain tumour
European Association of NeuroOncology Magazine 2012; 2 (3): 123-128
Combined fMRI and DTI tractography in a coronal view of a patient with
a tumour near the primary motor cortex. Displacement of both the primary motor
cortex (arrows) and the corticospinal tract (arrowheads) is seen. Keywords: brain,
fMRI,
Tumor
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