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Figures and Graphics
Smith ELK et al.  
Vascular endothelial growth factor (VEGF)and endothelin-3 (ET-3) activate cation currents in human umbilical vein endothelial cells

Journal of Clinical and Basic Cardiology 1998; 1 (1): 52-54

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Figure
 
VEGV und ET-3 - Gefäßpermeabilität
Figure 1: Effect of acute exposure to vascular endothelial growth factor (VEGF) on whole cell currents recorded from human umbilical vein endothelial cells (HUVEC) on the edge of a regrowing boundary. Whole cell currents before (upper traces) and at the end of 10 min in VEGF (20 pmol/L) containing solution (middle traces). From a holding potential of -60mV, brief pulses to -100, -60, -20 and +40mV were applied (pulse protocol shown in bottom trace). Whole cell capacitance 24 pF, series resistance 5.5 MΩ. Currents are shown with residual capacity transients manually erased. Cell 601252.


Keywords: cationcurrentDiagrammEndothelendothelin-3endothelin-3endotheliumKationNabelschnurStromumbilical veinVascular Endothelial Growth FactorVascular Endothelial Growth Factor
 
 
VEGF und ET-3 - Gefäßpermeabilität
Figure 2: Current voltage relations derived from the same cell as in Figure 1, before (control) and at the end of a 10 min exposure to VEGF (20 pmol/L) then 60 min after VEGF removal (recovery). Note the inward rectifier current present at voltages more negative than -80mV throughout this recording.


Keywords: cationcurrentDiagrammEndothelendotheliumKationNabelschnurStromumbilical veinVascular Endothelial Growth FactorVascular Endothelial Growth Factor
 
 
VEGF und ET-3 - Gefäßpermeabilität
Figure 3: Effect of acute endothelin-3 (ET-3) treatment on whole cell currents recorded from a single HUVEC on the edge of a wound. Current voltage relations are shown before ET-3 application (control), at the end of a 10 min exposure to 100 nmol/L ET-3 after which ET-3 was removed, then 60 min after ET-3 removal (recovery). Cell 511072. Whole cell capacitance 29pF, series resistance 8 MOhm.


Keywords: cationcurrentDiagrammEndothelendothelin-3endothelin-3endotheliumKationNabelschnurStromumbilical vein
 
 
 
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