Derfler K, Goldammer A |
Combined LDL-Apheresis and Statin Treatment in Homozygous and Heterozygous Familial Hyperlipoproteinaemia
Journal of Clinical and Basic Cardiology 2001; 4 (2): 139-144
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Hypercholesterinämie - Triglyzeride
Figure 1: Triglyceride (TG) levels in patients with homozygous and heterozygous familial hypercholesterolaemia on long-term LDL-apheresis and concomitant (A) simvastatin (40 mg) or (B) atorvastatin (10 to 80 mg) therapy
Keywords: Apherese,
Apheresis,
Atorvastatin,
Atorvastatin,
Diagramm,
Heterozygotie,
Heterozygousity,
Homozygotie,
Homozygousity,
Hypercholesterinämie,
hypercholesterolaemia,
LDL,
LDL,
Simvastatin,
Simvastatin,
triglyceride,
Triglyzeride
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Hypercholesterinämie - LDL
Figure 2: LDL-cholesterol in patients with homozygous and heterozygous familial hypercholesterolaemia on long-term LDL-apheresis and concomitant (A) simvastatin (40 mg) or (B) atorvastatin (10 to 80 mg) therapy
Keywords: Apherese,
Apheresis,
Atorvastatin,
Diagramm,
Heterozygotie,
Heterozygousity,
Homozygotie,
Homozygousity,
Hypercholesterinämie,
hypercholesterolaemia,
LDL,
LDL-cholesterol,
Simvastatin
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Hypercholesterinämie - LDL
Figure 3: Time course of serum LDL-cholesterol levels in homozygous (n = 4) and heterozygous (n = 10) patients with familial hypercholesterolaemia undergoing LDL-apheresis treatment at weekly intervals. The recovery of LDL-cholesterol is given both the total value (mg/dl) and the percent decrease for the last 24 hours. These values were determined either without additional statin therapy for four weeks (wash-out period) or when patients were on 80 mg of atorvastatin for a four weeks.
Keywords: Apherese,
Apheresis,
Atorvastatin,
Atorvastatin,
Diagramm,
Heterozygotie,
Heterozygousity,
Homozygotie,
Homozygousity,
Hypercholesterinämie,
hypercholesterolaemia,
LDL,
LDL
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LDL-Apherese - Fibrinogen
Figure 4: Fibrinogen concentrations obtained in patients treated long-term with LDL-apheresis and addition of different statin therapy. A: simvastatin (40 mg), B: atorvastatin 10 to 80 mg
Keywords: Apherese,
Apheresis,
Atorvastatin,
Atorvastatin,
Diagramm,
fibrinogen,
fibrinogen,
LDL,
LDL,
Simvastatin,
Simvastatin
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