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Gasser R, Pätzold S, Holzwart E, Ablasser K, Kraigher-Krainer E, Friehs I, Lewinski D, Pieske B, Mächler H, Trantiner-Yates A, Tscheliessnig KH, Mangge H, Porta S, Gasser S Immunological Implications in Experimental Myocardial Ischaemia: MPO (Myeloperoxidase) Expression Is Differentially Regulated by Beta-Blockers, While CD80 Expression Remains Unaffected Journal of Clinical and Basic Cardiology 2011; 14 (1-4): 16-22 PDF Summary Overview
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Figure/Graphic 1: MPO Experiments It shows the results from real-time PCR measurements of all MPO experiments (o2ko: well-oxygenated, no ischaemia, no drug; n2ko: experimental ischaemia, no drug; o2at: well-oxygenated, no ischaemia, atenolol present; n2at: experimental ischaemia, atenolol present; o2neb: well-oxygenated, nebivolol present; n2neb: experimental ischaemia, nebivolol present). Using PCR for validation, we find that during experimental ischaemia, there is an up-regulation of MPO expression. There is a differential regulation between different beta-blockers during myocardial ischaemia, which warrants further investigation. |
Figure/Graphic 1: MPO Experiments
It shows the results from real-time PCR measurements of all MPO experiments (o2ko: well-oxygenated, no ischaemia, no drug; n2ko: experimental ischaemia, no drug; o2at: well-oxygenated, no ischaemia, atenolol present; n2at: experimental ischaemia, atenolol present; o2neb: well-oxygenated, nebivolol present; n2neb: experimental ischaemia, nebivolol present). Using PCR for validation, we find that during experimental ischaemia, there is an up-regulation of MPO expression. There is a differential regulation between different beta-blockers during myocardial ischaemia, which warrants further investigation. |