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Halestrap AP The Mitochondrial Permeability Transition - A Pore Way for the Heart to Die Journal of Clinical and Basic Cardiology 2002; 5 (1): 29-41 PDF Summary Overview
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Figure/Graphic 5: Mitochondrien - Permeabilität Pyruvate protects the heart against reperfusion injury through inhibiting MPTP opening and enhancing subsequent pore closure. Pore opening upon reperfusion was determined using the entrapment of pre-loaded 3H-DOG, whilst subsequent closure of the MPTP was detected by measuring the entrapment of 3H-DOG loaded after maximal recovery of the heart (post-loading). These protocols are illustrated in the Figure and further details are given in the text and reference [97] from where the data are taken. |
Figure/Graphic 5: Mitochondrien - Permeabilität
Pyruvate protects the heart against reperfusion injury through inhibiting MPTP opening and enhancing subsequent pore closure. Pore opening upon reperfusion was determined using the entrapment of pre-loaded 3H-DOG, whilst subsequent closure of the MPTP was detected by measuring the entrapment of 3H-DOG loaded after maximal recovery of the heart (post-loading). These protocols are illustrated in the Figure and further details are given in the text and reference [97] from where the data are taken. |