Betablocker - Metabolismus
Figure 1: Metabolic pathways of ß-adrenoceptor blocking drugs in the liver. Glu = Glucuronide. The numbers indicate the following metabolic pathways: 1) Glucuronidation of the drug at the OH group of the side chain. 2) Aromatic hydroxylation and subsequent glucuronidation partly combined with the steps described under 3 and 4 (---). 3) Oxidative desamination. 4) Ether cleavage to phenol. 5) N-desalcylation.


Keywords: beta-blocker,  Betablocker,  Leber,  liver,  metabolism,  Metabolismus,  Schema