VEGV und ET-3 - Gefäßpermeabilität
Figure 1: Effect of acute exposure to vascular endothelial growth factor (VEGF) on whole cell currents recorded from human umbilical vein endothelial cells (HUVEC) on the edge of a regrowing boundary. Whole cell currents before (upper traces) and at the end of 10 min in VEGF (20 pmol/L) containing solution (middle traces). From a holding potential of -60mV, brief pulses to -100, -60, -20 and +40mV were applied (pulse protocol shown in bottom trace). Whole cell capacitance 24 pF, series resistance 5.5 MΩ. Currents are shown with residual capacity transients manually erased. Cell 601252.


Keywords: cation,  current,  Diagramm,  Endothel,  endothelin-3,  endothelin-3,  endothelium,  Kation,  Nabelschnur,  Strom,  umbilical vein,  Vascular Endothelial Growth Factor,  Vascular Endothelial Growth Factor

VEGF und ET-3 - Gefäßpermeabilität
Figure 2: Current voltage relations derived from the same cell as in Figure 1, before (control) and at the end of a 10 min exposure to VEGF (20 pmol/L) then 60 min after VEGF removal (recovery). Note the inward rectifier current present at voltages more negative than -80mV throughout this recording.


Keywords: cation,  current,  Diagramm,  Endothel,  endothelium,  Kation,  Nabelschnur,  Strom,  umbilical vein,  Vascular Endothelial Growth Factor,  Vascular Endothelial Growth Factor

VEGF und ET-3 - Gefäßpermeabilität
Figure 3: Effect of acute endothelin-3 (ET-3) treatment on whole cell currents recorded from a single HUVEC on the edge of a wound. Current voltage relations are shown before ET-3 application (control), at the end of a 10 min exposure to 100 nmol/L ET-3 after which ET-3 was removed, then 60 min after ET-3 removal (recovery). Cell 511072. Whole cell capacitance 29pF, series resistance 8 MOhm.


Keywords: cation,  current,  Diagramm,  Endothel,  endothelin-3,  endothelin-3,  endothelium,  Kation,  Nabelschnur,  Strom,  umbilical vein