Figure/Graphic 1a-c: Glycosaminoglycans and Glioma Invasion
(A) Schematic representation of heparan sulphate (HS) proteoglycan and chondroitin sulphate (CS) proteoglycan biosynthesis and chain modifications. (B) Heparan sulphate proteoglycans (HSPG) act as co-receptors for growth factor (GF) signalling via growth factor receptors (GFR), thereby promoting cell proliferation, angiogenesis, and migration. (C) Degradation of HSPG by heparanase (Hpse) contributes to ECM degradation and release of HS-bound growth factors.