Abbildung 2: Angiotensin-II-Antagonisten
Telmisartan, a potent and highly selective AT1 receptor antagonist, displays a novel bis-benzimidazole structure. This unique feature of telmisartan accounts for both its high receptor affinity and its excellent pharmacokinetic properties.1 This slide shows the active metabolites of losartan, candesartan and olmesartan. The chemical structures of valsartan, irbesartan and eprosartan are also shown. 1. Ries UJ, et al. 6-Substituted benzimidazoles as new nonpeptide angiotensin II receptor antagonists: synthesis, biological activity, and structure–activity relationships. J Med Chem 1993; 36: 4040–4051.