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Zweiker R et al.
Carvedilol and Hydrochlorothiazide in Hypertensives with Metabolic Disorder: Not Always Bad News - An Austrian Survey

Journal für Hypertonie - Austrian Journal of Hypertension 2009; 13 (2): 22-26

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Betablockers are no longer regarded as first-choice therapy in the treatment of uncomplicated hypertension. However, they cannot be dismissed from the optimum treatment of many cardiovascular diseases. It seems important to distinguish between betablockers of past generations and new generations with vasodilating properties. Our data show that the third-generation betablocker carvedilol does not worsen the metabolic status of patients even if it is combined with low doses of a thiazide diuretic. These considerations should have impact on the choice of therapy.
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