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Sagcan A et al.  
In-vitro-Response of Platelet Aggregation Induced by Various Agonists in Chronic Smoking Coronary Artery Disease Patients

Journal of Clinical and Basic Cardiology 2003; 6 (1-4): 55-57

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Keywords: Angina pectorisKardiologieKoronare HerzkrankheitPlättchenaggregationRauchencardiologycoronary artery diseaseplatelet aggregationSmokingstable angina pectorisunstable angina pectoris

Background: Chronic cigarette smoking (CCS) is known as one of the major risk factors in the development of atherosclerosis. The relationship between smoking and coronary artery disease (CAD) has been established by epidemiological studies. Smoking has also been shown to have negative effects on haemostatic balance especially on platelet function. Aim: In this study, the effect of CCS on in-vitro-platelet-aggregation induced by various agonists was investigated in coronary artery disease patients. Methods: One hundred and twenty-one patients with stable angina pectoris and controlled unstable angina pectoris were included in the study. Patients were divided into two groups: Group I consisted of 53 CCS patients and Group II consisted of 68 non-smokers. Agonist induced platelet aggregation (PA) waves were measured by turbidometric method of Born. Maximum amplitude and duration of aggregation waves for each of the agonists were calculated. Results: Maximum amplitude and duration of ADP, collagen, and epinephrine induced in vitro PA response were significantly higher in Group I (p-values respectively: p < 0.05, p < 0.0001, p < 0.0001). Conclusion: In vitro PA response is increased despite antiaggregant therapy in CAD patients who are chronic smokers. Further studies are needed to establish the effect of smoking cessation on PA and progression of CAD. We also believe that prospective studies are needed to show the effect of more efficient antiaggregant therapy for CAD patients who are chronic smokers.
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