Sympathikus-Überaktivität aus dem Blickwinkel der Nephrologie
Journal für Hypertonie - Austrian Journal of Hypertension 2004; 8 (Sonderheft 2): 17-19
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Keywords: Hypertonie, Nephrologie, Sympathikus
Several factors including sodium retention, volume expansion and increased activity of the reninangiotensin-aldosterone-system have been described in the pathogenesis of chronic renal insufficiency. Recent studies provide evidence for a role of the activated sympathetic nervous system. Renal afferent activity could directly activate specific regions in the brain, which are involved in the regulation of blood pressure and could induce blood pressure increase by efferent signals. A new group of antihypertensive drugs, the I1-imidazoline-receptor antagonists (Rilminedine), bring in a new starting point for treatment of hypertension in patients with chronic renal insufficiency. Recent data show that Rilmenidine does not only lower blood pressure, but also prevents end organ damage like left ventricular hypertrophy or microalbuminuria leading to a cardiovascular risk reduction.