Endothelium-Dependent and -Independent Vasodilation in Young Males with Previous Myocardial Infarction
Journal of Clinical and Basic Cardiology 2003; 6 (1-4): 73-76
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Keywords: Endothel, Kardiologie, Mann, Myokardinfarkt, Vasodilatation, cardiology, endothelium, Male, myocardial infarction, Vasodilatation
Flow-mediated vasodilation - a non-invasively measurable index of endothelial function - is a good predictor of cardiovascular risk. This study was undertaken to analyse the correlation between flow-mediated vasodilation and the severity of coronary artery disease in males less than 40 years of age and with myocardial infarction in their history. Coronary angiography demonstrated single-vessel disease in 16 patients (Group A) and multi-vessel disease in 12 (Group B). The control group comprised 14 healthy young males (Group C). Endothelium-dependent vasodilation produced by reactive hyperaemia, as well as nitroglycerine-induced, endothelium-independent vasodilation was appraised on the brachial artery, using a high-resolution duplex ultrasound device (ACUSON 128XP/10). Variations in vessel size recorded as prescribed by the protocol developed by Celermayer were expressed as percentage change compared to baseline. Compared to controls, endothelium-dependent vasodilation was attenuated in patients with previous myocardial infarction (p < 0.01). The same applies to multi-vessel disease, in comparison to single-vessel disease. There was no difference between controls and postinfarction patients as regards nitroglycerine-induced vasodilation. Endothelium-dependent vasodilation is diminished in young males with previous myocardial infarction, and the magnitude of this reduction is related to the severity of coronary artery disease.
Journal of Clinical and Basic Cardiology 2003; 6 (1-4): 73-76
PDF Summary Figures
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Keywords: Endothel, Kardiologie, Mann, Myokardinfarkt, Vasodilatation, cardiology, endothelium, Male, myocardial infarction, Vasodilatation
Flow-mediated vasodilation - a non-invasively measurable index of endothelial function - is a good predictor of cardiovascular risk. This study was undertaken to analyse the correlation between flow-mediated vasodilation and the severity of coronary artery disease in males less than 40 years of age and with myocardial infarction in their history. Coronary angiography demonstrated single-vessel disease in 16 patients (Group A) and multi-vessel disease in 12 (Group B). The control group comprised 14 healthy young males (Group C). Endothelium-dependent vasodilation produced by reactive hyperaemia, as well as nitroglycerine-induced, endothelium-independent vasodilation was appraised on the brachial artery, using a high-resolution duplex ultrasound device (ACUSON 128XP/10). Variations in vessel size recorded as prescribed by the protocol developed by Celermayer were expressed as percentage change compared to baseline. Compared to controls, endothelium-dependent vasodilation was attenuated in patients with previous myocardial infarction (p < 0.01). The same applies to multi-vessel disease, in comparison to single-vessel disease. There was no difference between controls and postinfarction patients as regards nitroglycerine-induced vasodilation. Endothelium-dependent vasodilation is diminished in young males with previous myocardial infarction, and the magnitude of this reduction is related to the severity of coronary artery disease.