Cholangiokarzinom
Abbildung 1: Signalwege und Angriffspunkte der molekularen Therapien beim Cholangiokarzinom. Erstellt nach Daten aus [65]. EGRF: epidermal growth factor receptor; VEGFR: vascular endothelial growth factor receptor; RAS: rat sarcoma protein; PI3K: Phosphatidylinositol-3-Kinase; BRAF: v-Raf murine sarcoma viral oncogene homolog B1; PIP2: Phosphatidylinositol-4,5-Bisphosphat, PIP3: Phosphatidylinositol-3,4,5-Triphosphat; MEK: mitogen-activated protein kinase/extracellular-signal regulated kinase; PTEN: phosphatase and tensin homolog; Rheb: RAS homolog enriched in brain; TSC: tuberous sclerosis complex; AKT: protein kinase B; mTOR: mammalian target of rapamycin.


Keywords: Cholangiokarzinom,  molekulare Therapie,  Schema