Vitamin D
Abbildung 1a-b: 1a: Data points and represented trial from left to right: 340 IU = Lips [65], 376 IU = Record [11], 380 IU = Meyer [21], 482 = WHI (study medication plus personal intake) [10], 640 IU (D3) = Trivedi [66], 640 IU = Lyons [20], 651 IU = Dawson-Hughes [67], 664 IU = Chapuy 1992 [68], 700 IU = Pfeifer 2009 [69], 760 IU = Chapuy 2002 [70], 768 IU = Pfeifer 2000 [71], 770 IU = Flicker [63]. 1b: Data points and represented trial from left to right: 62 nmol/l = Lips [65], 62 nmol/ l = Record [11], 64 nmol/l = Meyer [21], 66 nmol/l = Pfeifer 2000 [71], 74 nmol/l = Trivedi [66], 78 nmol/l = Chapuy 2002 [70], 80 nmol/l = Lyons [20], 84 nmol/l = Pfeifer 2009 [69], 105 nmol/l = Chapuy 1992 [68], 112 nmol/l = Dawson-Hughes [67]. Figure 1a, b: Prevention of non-vertebral fractures with oral vitamin D and dose dependency: a meta-analysis of randomized controlled trials. Triangles indicate trials with D3, circles trials with D2. Line = Trendline. All 12 high quality trials were included for the received dose meta-regression (n = 42,279 individuals). For achieved 25(OH)D levels 2 trials did not provide serum 25(OH)D levels measured in the study population during the trial period [63, 64]. For any non-vertebral fractures, anti-fracture efficacy increased significantly with higher received dose (meta-regression: Beta = –0.0007; p = 0.003) and higher achieved 25-hydroxyvitamin D levels (meta-regression: Beta = –0.005; p = 0.04) (adapted from [9]).


Keywords: chart,  Diagramm,  Mineralstoffwechsel,  Vitamin D

Fall-Fracture-Prevention
Abbildung 2: Threshold for optimal fall and fracture prevention based on double-blind randomized controlled trials. Data points show the relative risk of falls and the relative risk of sustaining any nonvertebral fracture from double-blind RCTs, by achieved 25-hydroxyvitamin D levels in the treatment groups. Data was extracted from two 2009 meta-analyses [8, 9] and summarized in a recent benefit-risk analysis of vitamin D [29]. Based on these data, 75 or better 100 nmol/l (30 or better 40 ng/ml) are suggested as an optimal threshold of 25-hydroxyvitamin D for fall and fracture prevention


Keywords: chart,  Diagramm,  fallprevention,  Fallprävention,  fractureprevention,  Frakturprävention,  Mineralstoffwechsel