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Gasser R, Ablasser K, Roessl U, Kraigher-Krainer E, Lewinski D, Mangge H, Mächler H, Trantina-Yates A, Tscheliessnigg KH, Udermann H, Porta S, Friehs I, Scherr E, Brussee H, Gasser S Differential Gene Expression und Nebivolol and Atenolol during Experimental Ischemia in Human Myocardium Journal of Clinical and Basic Cardiology 2008; 11 (1-4): 16-23 PDF Summary Overview
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Figure/Graphic 6a-b: Biochemical process In well-oxygenized preparations, we can see that numerous biochemical processes, mainly those involved in signalling and cellular immunity, are affected by nebivolol but not by atenolol. In the lower part, we can see that many processes involved in contraction, lipid metabolism, and proliferation are down-regulated by nebivolol only (not by atenolol). This kind of processes, if slowed down, may render the heart less vulnerable to O2 deficit or ischemia. |
Figure/Graphic 6a 
Figure/Graphic 6b 
Figure/Graphic 6a-b: Biochemical process
In well-oxygenized preparations, we can see that numerous biochemical processes, mainly those involved in signalling and cellular immunity, are affected by nebivolol but not by atenolol. In the lower part, we can see that many processes involved in contraction, lipid metabolism, and proliferation are down-regulated by nebivolol only (not by atenolol). This kind of processes, if slowed down, may render the heart less vulnerable to O2 deficit or ischemia. |