Figure/Graphic 4a-c: Koronararterien - Relaxation
A: Dinitrophenole (1 mM), an uncoupler of oxidative phosphorylation invariably leads to vasodilation, the latter is partially inhibited by glibenclamide in a dose-dependent manner; B: Dose dependent inhibition of DNP-induced vasodilation; note repaglinide’s intrinsic relaxing activity at higher doses; the inhibition of relaxation is not as pronounced as with glimepiride and glibenclamide; C: Inhibition of DNP induced relaxation is maximal under 3 µM glimepiride; the effect of a similar dose of glibenclamide is also introduced in this figure in order to demonstrate the approximate equimolar inhibition; glimepiride is a stronger inhibitor of DNP-induced vasorelaxation than glibenclamide.