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Gasser R, Esche G, Gasser S, Holzmann S, Köppel H, Moosbrugger B, Salzer M Indiscriminative Effects of Repaglinide and Other Specific Modulators of Transmembrane KATP-Channel Gating Properties upon Ischaemic/Hypoxic Bovine Coronary Artery Smooth Muscle Relaxation Journal of Clinical and Basic Cardiology 2003; 6 (1-4): 81-85 PDF Summary Overview
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Figure/Graphic 5a-c: Koronararterien - Relaxation A: Iodoacetic acid (IAA), an inhibitor of the glycolytic enzyme G3P-dehydrogenase leads to vasodilation; inhibition by glibenclamide, repaglinide and glimepiride (B) is insignificant; only a dose of 1 µM repaglinide is able to inhibit IAA-induced vasorelaxation after 10 min by 20 %. |
Figure/Graphic 5a-c: Koronararterien - Relaxation
A: Iodoacetic acid (IAA), an inhibitor of the glycolytic enzyme G3P-dehydrogenase leads to vasodilation; inhibition by glibenclamide, repaglinide and glimepiride (B) is insignificant; only a dose of 1 µM repaglinide is able to inhibit IAA-induced vasorelaxation after 10 min by 20 %. |