Figure/Graphic 1: MGMT
Effect of MGMT promoter methylation status in glioblastomas. In GBM, hypermethylation of the MGMT promoter results in reduction of MGMT protein, which in turn leads to improved chemosensitivity for TMZ chemotherapy or combined radiochemotherapy. Therefore, MGMT promoter methylation is correlated with improved overall survival in these patients. In contrast, GBM patients with unmethylated MGMT promoter status may have reduced response to radio-/chemotherapy and therefore worse prognosis (mod from [1, 17]).