Figure/Graphic 2: Glioblastoma
Possible genetic pathways in glioblastomas. Glioblastomas can be differentiated into primary GBM (de novo occurrence) or secondary GBM, which originate from either a low-grade diffuse astrocytoma (WHO grade II) directly or via malignant transformation from an anaplastic astrocytoma WHO grade III. It has been demonstrated that both GBM pathways show genetic alterations at different time points and/ or in a different frequency. Some of them are shown in this figure which was modified from the literature [46].