Figure/Graphic 3A-C: Kalziumkanal - Mibefradil
Effects of 1 micromol/l mibefradil on T-type (A), L-type (B), and composite (C) Ba2+ current (IBa). (o conforms control group, black square conforms 1 microM mibefradil treated group). A: T-type IBa (VT= -20 mV from VH= -80 mV) was 80 % inhibited after 5 minutes by 1 micromol/l mibefradil. B: L-type IBa (VT= +20 mV from VH= -30 mV) was reduced by only 28 % after 8 minutes in 1 micromol/l mibefradil. C: The T-type peak and the same 28 % of L-type IBa as in B were blocked at 5 minutes by 1 micromol/l mibefradil (VT= +20 mV from VH= -80 mV). All tracings are from the same vascular muscle cell.