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März W, Winkelmann BR  
HMG-CoA Reductase Inhibition in the Treatment of Atherosclerosis: Effects Beyond Lipid Lowering

Journal für Kardiologie - Austrian Journal of Cardiology 2002; 9 (7-8): 284-294

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Simvastatin - Schlaganfall
Abbildung 1: Left panel: Effect of increasing doses of simvastatin administered for two weeks on the volume of cerebral infarcts and a neurological sensory-motor score in mice induced by occlusion of the main carotid artery. Right panel: The effect is abolished in mice lacking endothelial nitric oxide. Modified according to Endres et al. [41].

Keywords: DiagrammKardiologieNeurologieSchlaganfallSimvastatinStatin
Pravastatin - C-reaktives Protein
Abbildung 2: Pravastatin and C-reactive protein. A. Relative risks of recurrent coronary events in patients with previous MI in the CARE trial according to the presence (both C-reactive protein and serum amyloid A (> 90th percentile) or absence of systemic inflammation and according to treatment group [93]. B. C-reactive protein in a subset of 472 participants of the CARE study who remained free of coronary event during the trial. Left panel: Median and mean values at baseline and at 5 years of follow-up. Right panel: Mean changes over time stratified according to changes in LDL cholesterol in the placebo and in the pravastatin group. Modified according to [95].

Keywords: C-reaktives ProteinCARE-StudieDiagrammKardiologiekoronares EreignisLDL-CholesterinMyokardinfarktPravastatinRisikoSerumamyloid AStatin
Pravastatin - Plaque
Abbildung 3: Effect of statin treatment on the composition of atherosclerotic plaques. Consecutive patients with symptomatic carotid artery stenoses received 40 mg daily pravastatin (n = 11) or no lipid-lowering therapy (n = 13) for 3 months before elective carotid endarterectomy. Carotid plaque composition was assessed with special stains and immunocytochemistry with quantitative image analysis. Compared to controls, pravastatin decreased the contents lipids, oxidized LDL, macrophages, T cells, matrix metalloproteinase 2 (MMP-2) and apoptotic cells, but increased the tissue inhibitor of metalloproteinase 1 (TIMP-1) and collagen. A slight increase in smooth muscle cells was also observed. Modified according to [147].

Keywords: Arteria carotisAtheroskleroseDiagrammKardiologiePatientPlaquePlaquestabilitätPravastatinStatinStenose
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