Adenosin und koronare Mikrozirkulation
Figure 1: Experimental protocol


Keywords: Adenosin,  adenosine,  Design,  ischaemia,  Ischämie,  microcirculation,  Mikrozirkulation,  Schema

Adenosin und koronare Mikrozirkulation
Figure 2: Heart weight changes: wet weight/dry weight (ww/dw) in all experimental groups. Data are expressed as mean and SD: * = p < 0.01 vs. KH perfused hearts.


Keywords: Adenosin,  adenosine,  Diagramm,  ischaemia,  Ischämie,  microcirculation,  Mikrozirkulation

Adenosin und koronare Mikrozirkulation
Figure 3: Time course of coronary flow (CF: ml/min) in nonischaemic hearts (top) and after 10 (middle) and 20 min. (bottom) ischaemia. Data are expressed as mean and SD; * = p < 0.01 vs. KH perfusion.


Keywords: Adenosin,  adenosine,  Diagramm,  ischaemia,  Ischämie,  microcirculation,  Mikrozirkulation

Adenosin und koronare Mikrozirkulation
Figure 4: Purine release (nmol x min-1 x gr.dw-1). Time course of nucleosides (adenosine, inosine) and metabolites (hypoxanthine and uric acid) in all groups. Data are expressed as mean and SD. * = p = 0.05; ** = p < 0.001.


Keywords: Adenosin,  adenosine,  Diagramm,  ischaemia,  Ischämie,  microcirculation,  Mikrozirkulation,  Purin,  purine

Adenosin und koronare Mikrozirkulation
Figure 5: Effects of DPCPX on microvascular permeability. Quantitative assessment of FITC-albumin extravasation expressed as IOI (integrated optical intensity; see Material and methods) units; data are expressed as mean and SD. * = p < 0.02 vs. KH.


Keywords: Adenosin,  adenosine,  Diagramm,  ischaemia,  Ischämie,  microcirculation,  Mikrozirkulation

Adenosin und koronare Mikrozirkulation
Figure 6: Histological samples (200x, fluorescent light) showing the FITC-albumin diffusion. A: control heart submitted to 20 min global ischaemia, B) effect of 100 nm DPCPX: a significant reduction of perivascular (PV, left) and perimyocytic (PM, right) fluorescence is detected.


Keywords: Adenosin,  adenosine,  Histologisches Präparat,  histology,  ischaemia,  Ischämie,  microcirculation,  Mikrozirkulation

Adenosin und koronare Mikrozirkulation
Figure 7A-B: Ultrastructural morphometry (4500x). A: longitudinal section of control rat heart subjected to 20 min. ischaemia and reperfusion; interstitial and interfibrils oedema, severe mitochondria damage and endothelial lesions are detected. B: effect of DPCPX 100 nM: a significant reduction of ultrastructural damage is reported. M: mitochondria, ISE: interstitial oedema, IFE: nterfibrils oedema, E: endothelium.


Keywords: Adenosin,  adenosine,  Histologisches Präparat,  histology,  ischaemia,  Ischämie,  microcirculation,  Mikrozirkulation