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Conci E et al.  
Mouse Models for Myocardial Ischaemia/Reperfusion

Journal für Kardiologie - Austrian Journal of Cardiology 2006; 13 (7-8): 239-244

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Adhesion Molecules
Abbildung 1: Scheme of involvement of the adhesion molecules in ischaemia/reperfusion. Under normal conditions, there are virtually no interactions between the endothelium and neutrophils. After coronary ischaemia/reperfusion, the blood vessel’s ability to form NO is severely reduced. With decreased supplies of NO, the coronary vessel may constrict. Additional adhesion molecules were expressed on the endothelium and polymorphonuclear leukocytes (PMNs) begin with rolling as the first step in PMN sequestration. As the PMN slows, tighter interactions between CD18 (on PMN) and ICAM-1 (on endothelium) cause the second phase of the PMN-EC interaction called sticking. The final step, the diapedesis, involves the coordination of many factors.

Keywords: Kardiologiemyokardiale IschämiePerfusionSchema
Mouse model
Abbildung 2: Open mouse chest with occluded left descending coronary artery. Photograph of open chest mouse with occluded left descending coronary artery by the help of a PE-10 plastic tubing. The LAD ligation was done with an 8-0 silk and was evident by discoloration of the left ventricle. Arrows indicate the area at risk.

Keywords: FotoKardiologielinke KoronararterieMausmodell
TTC-stained heart
Abbildung 3: Cross sections of the TTC-stained heart. a) Areas at risk are delineated by Evans blue dye in a representative heart with occlusion of the left descending coronary artery. All areas that stain blue were therefore not at risk. b) Areas that appear pale white are infarcted. Areas that remain red were not infarcted but were within the area at risk. Transverse sections are from the apex to the base (from left to right side).

Keywords: EvansKardiologieTTC
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