Abbildung 1a-d: Homologous Chromosomes
1. (A): Pachytene chromosome axes (SCs) of a wild-type mouse revealed by SYCP3 immunostaining (B): Atm–/– zygotene-like spermatocyte which displays pairing errors (arrow). In this condition SC formation is never complete. For details see [78]. (C): Wild-type spermatocyte stained for the cohesin subunit STAG3 (green, SCs) and fluorescence in situ hybridization of telomeres (red). Wild-type chromosome axes (SCs) are long and capped by a distinct telomere signal. (D): In the Smc1β–/– spermatocyte, chromosome axes and SCs are hyper-condensed and significantly shorter than in the wild type. For details see [79]. Magnification 630× in the original.