Abbildung 11: EUROPA-Studie - Blutdruck
The blood pressure reduction over 24 h minimizes the risk of stroke and myocardial infarction in the early morning hours. In the randomized, parallel study, 293 mild-to-moderate essential hypertensive patients were treated with perindopril 4 to 8 mg once daily or placebo for 12 weeks. Trough-to-peak ratio (TPR) in placebo-corrected diastolic blood pressure at 24 h versus 6 h was 100 %, and 97 % for 4 mg and 8 mg, respectively. A linear relationship in efficacy between the dose of perindopril and the reduction in blood pressure was demonstrated over the range of 4 mg to 8 mg once daily over the 24 h.