Abbildung 44: EUROPA-Studie - Myokardinfarkt
Perindopril 8 mg once daily reduced myocardial infarction (fatal or non-fatal) by 24 % (p < 0.001). This is one of the most impressive results as curves separated early and there was a tendency for the gap between curves to widen more in time even after the end of the study follow up. As Dr Harvey White, from Cardiology Dept. Green Lane hospital, NZ commented in the EUROPA editorial: "Although the blood pressure reduction in EUROPA was small (5 mm Hg systolic and 2 mm Hg diastolic), the systolic pressure reduction might be expected to translate into a 10 % reduction in myocardial infarction, whereas the actual reduction in non-fatal MI was 24 %". This demonstrates that BP reduction should not be the predominant mechanism of benefit with perindopril.